Division: Biochemistry

Title: Professor

Specialties:

Biochemistry and Bioinformatics

Bioinformatics and Biomedicals Science, especially Drug Discovery and Development.

Usman Sumo Friend Tambunan is Professor of the Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Indonesia since 1997. He earned his Dr. degree in Chemistry from Tohoku University, Japan in 1986 under Prof. Sho Ito supervision with dissertation title of “Synthetic Studies on Polycyclic Terpenoids (-)-Vitrenal and (±)-Lauren-1-ene”. Afterward, he carried out postdoctoral research at Kansas University, Battelle Memorial Institute, Colombus, Ohio, USA and in Taiwan to study pharmaceutical biotechnology. Since then, he has been a lecturer for Organic Chemistry and Biochemistry at Universitas Indonesia. He has been appointed to several positions at Universitas Indonesia, such as Vice Dean I of Faculty of Mathematics and Natural Science (2001-2004) and Chief of Professor Council at Faculty of Mathematics and Natural Science (2007-2015). Additionally, he also worked as Senior Scientist at Badan Pengkajian dan Penerapan Teknologi (BPPT), Energy Resources Division (1986-1993). Currently, he also served as the editor of several prestigious journals,such as Asian Journal of Biological Sciences, International Journal of GEOMATE, Open Biochemistry Journal, Molecules, Revista Brasileira de Farmacognosia, Lecture Notes in Computer Science and Biochemistry Insight. Moreover, he has been selected as the Associate member of Institute of Integrative Omics and Applied Biotechnology (IIOAB).

Prof. Tambunan research interests focus on drug and vaccine design using computational method (in silico approach) for avian influenza (H5N1, H1N1, H7N9), Ebola virus, dengue virus, diabetes mellitus, breast cancer, tuberculosis, and cervical cancer. His research includes the development of natural products (such as flavonoids and stilbenoids), cyclic peptides, peptides and fragment-based drug design to find better drug candidate to combat these diseases. Moreover, he is also specialized in enzyme stability and bioinorganic chemistry studies of the ligand-enzyme complex as well. His research has been funded by Ministry of Research Development (through Hibah KEMENRISTEK/BRIN, and Directorate of Research and Development Universitas Indonesia).

1. Exemplary Lecturer, Faculty of Mathematics and Natural Sciences at Universitas Indonesia(1989-1990).
2. Sapta Lencana Karya Satya 10 years of dedication (1998).
3. Best Researcher 3 rd place in Sciences and Technologies, Universitas Indonesia (2008).
4. Best Researcher 3 rd place in Sciences and Technologies, Universitas Indonesia (2009).
5. Best Professor 3 rd place, Universitas Indonesia (2009).
6. Satya Lencana Karya 30 years of dedication (2010).
7. HAKI Awardee Universitas Indonesia

• 1. Alkaff, A. H., Saragih, M., Imana, S. N., Nasution, M. A. F. & Tambunan, U. S. F. Identification of DNA Methyltransferase-1 Inhibitor for Breast Cancer Therapy through Computational Fragment-Based Drug Design. Molecules (2021) doi:10.3390/molecules26020375.
  2. Saragih, M., Stephanie, F., Alkaff, A. H. & Tambunan, U. S. F. Identification of Novel Peptides Targeting DNA Methyltransferase 1 (DNMT-1) for Breast Cancer Treatment. Rev. Bras. Farmacogn. (2020) doi:10.1007/s43450-020-00086-6.
  3. Fatonah, A., Tambunan, U. S. F., Pamungkas, W. O., Dewanto, G. L. & Wicaksono, I. S. Discovery of GPX4 inhibitor by molecular docking simulation as a potential ferroptosis inducer. Biointerface Res. Appl. Chem. (2020) doi:10.33263/BRIAC101.929933.
  4. Samada, L. H. & Tambunan, U. S. F. Biopesticides as promising alternatives to chemical pesticides: A review of their current and future status. Online J. Biol. Sci. (2020) doi:10.3844/ojbsci.2020.66.76.
  5. Fleming, V. J., Saragih, M. & Tambunan, U. S. F. Utilization of Flavonoid Compounds as HER2 Tyrosine Kinase Inhibitor in Breast Cancer Using Fragment-Based Drug Design. Key Eng. Mater. 840, 230–236 (2020).
  6. Ariavianti, E., Stephanie, F. & Tambunan, U. S. F. Virtual screening based on pharmacophore to discover host ER alpha- glucosidase II inhibitor for dengue therapy. in Key Engineering Materials (2020). doi:10.4028/www.scientific.net/kem.840.221.
  7. Bagastama, A. R., Alkaff, A. H. & Tambunan, U. S. F. Discovery of natural product compounds as dengue virus NS5 methyltransferase inhibitor candidate through in silico method. in Key Engineering Materials (2020). doi:10.4028/www.scientific.net/kem.840.270.
  8. Imana, S. N., Ningsih, E. G. & Tambunan, U. S. F. In silico identification of peptide as epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer treatment. Pakistan J. Biol. Sci. (2020) doi:10.3923/pjbs.2020.567.574.
  9. Alkaff, A. H., Yohan, B., Tambunan, U. S. F. & Tedjo Sasmono, R. Zika, chikungunya, and dengue viral infections in human peripheral blood mononuclear cells: Cell susceptibility and gene expression. Med. J. Indones. (2020) doi:10.13181/mji.oa.193548.
  10. Hidayat, M. F., Ningsih, E. G., Alkaff, A. H. & Tambunan, U. S. F. Discovery of novel α-amylase inhibitors as type two diabetes mellitus therapy through fragment-based drug design. Key Eng. Mater. 840 KEM, 237–244 (2020).
  11. Alkaff, A. H., Saragih, M., Fardiansyah, M. A. & Tambunan, U. S. F. Role of Immunoinformatics in Accelerating Epitope-Based Vaccine Development against Dengue Virus. Open Biochem. J. 14, 9–18 (2020).
  12. Alkaff, A. H., Saragih, M., Nasution, M. A. F. & Tambunan, U. S. F. Inhibition of Primed Ebola Virus Glycoprotein by Peptide Compound Conjugated to HIV-1 Tat Peptide Through a Virtual Screening Approach. in Computational Intelligence Methods for Bioinformatics and Biostatistics,15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018, Revised Selected Papers, LNBI (2020). doi:10.1007/978-3-030-34585-3_14.
  13. Nasution, M. A. F., Alkaff, A. H., Rizki, I. F., Bakri, R. & Tambunan, U. S. F. Pharmacophore Modelling, Virtual Screening, and Molecular Docking Simulations of Natural Product Compounds as Potential Inhibitors of Ebola Virus Nucleoprotein. in Computational Intelligence Methods for Bioinformatics and Biostatistics,15th International Meeting, CIBB 2018, Caparica, Portugal, September 6–8, 2018, Revised Selected Papers, LNBI (2020). doi:10.1007/978-3-030-34585-3_15.
  14. Puspitasari, R. D., Tambunan, U. S. F. & Dewanto, G. L. The development of novel HPV drugs by HDAC inhibitor based upon applied bioinformatics tool and their specialized algorithm. Biointerface Research in Applied Chemistry (2019) doi:10.33263/BRIAC95.428432.
  15. Saragih, M., Stephanie, F., Alkaff, A. H. & Tambunan, U. S. F. Identification novel peptides conjugated to hiv1 tat peptide to inhibit ebola virus entry by targeting niemann pick C1 protein. in Proceedings – 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (2019). doi:10.1109/BIBE.2019.00017.
  16. Stephanie, F., Saragih, M., Alkaff, A. H., Nasution, M. A. F. & Tambunan, U. S. F. Screening of potential northern african natural product compounds as dengue virus NS5 methyltransferase inhibitor: An in silico approach. in Proceedings – 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (2019). doi:10.1109/BIBE.2019.00046.
  17. Ernawan, B., Surniyantoro, H. N. E., Sugoro, I. & Tambunan, U. S. F. A mutant variant of Nix gene on γ-irradiated Aedes aegypti as a male-determination factor. Biodiversitas J. Biol. Divers. 20, 893–899 (2019).
  18. Tambunan, U. S. F., Parikesit, A. A., Ghifari, A. S. & Satriyanto, C. P. In silico identification of 2-oxo-1,3-thiazolidine derivatives as novel inhibitor candidate of class II histone deacetylase (HDAC) in cervical cancer treatment. Arab. J. Chem. 12, 272–288 (2015).
  19. Fatonah, A., Satrio Wicaksono, I. & Tambunan, U. S. F. Strategies of tuberculosis-HIV vaccines design using immunoinformatic approach. Online J. Biol. Sci. 19, 110–116 (2019).
  20. Yulianti, Kantale, A. C. B. & Tambunan, U. S. F. Discovery of Novel Alpha-Amylase Inhibitors for Type II Diabetes Mellitus Through the Fragment-Based Drug Design. Medicine Sciences and Bioengineering (Springer International Publishing, 2019). doi:10.1201/b18418-68.
  21. Ningsih, E. G., Hidayat, M. F. & Tambunan, U. S. F. Fragment-Based Drug Design to Discover Novel Inhibitor of Dipeptidyl Peptidase-4 (DPP-4) as a Potential Drug for Type 2 Diabetes Therapy. in Medicine Sciences and Bioengineering vol. 4 14–24 (Springer International Publishing, 2019).
  22. Saragih, M., Alkaff, A. H., Natalia, A. H., Istiqomah, I. N. & Tambunan, U. S. F. Discovery of Novel Dnmt-1 Inhibitor By Fragment-Based Drug Design As a Potential Breast Cancer Treatment. J. Geomate 17, 41–46 (2019).
  23. Natalia, A. H., Alkaff, A. H., Saragih, M., Istiqomah, I. N. & Tambunan, U. S. F. Fragment-Based Drug Design To Inhibit Dna Methyltransferase 1 ( Dnmt1 ) for Breast Cancer Therapy. J. Geomate 17, 35–40 (2019).
  24. Tio, G. A. et al. Structure-Based Virtual Screening of Indonesian Natural Product Compounds As Ebola Virus Vp30 Protein Inhibitors. J. Geomate 17, 208–214 (2019).
  25. Nasution, M. A. F., Toepak, E. P., Alkaff, A. H. & Tambunan, U. S. F. Flexible docking-based molecular dynamics simulation of natural product compounds and Ebola virus Nucleocapsid (EBOV NP): A computational approach to discover new drug for combating Ebola. BMC Bioinformatics 19, 137–176 (2018).
  26. Parikesit, A. A. & Tambunan, U. S. F. Computational protein design in green chemistry. Rasayan J. Chem. 11, 1133–1138 (2018).
  27. Tambunan, U. S. F. Changes in germs: A potential preemptive strike against the next pandemic. J. Med. Sci. 18, 48–55 (2018).
  28. Tambunan, U. S. F., Siregar, S. & Toepak, E. P. EBOLA VIRAL PROTEIN 24 ( VP24 ) INHIBITOR DISCOVERY BY IN SILICO FRAGMENT-BASED DESIGN. J. Geomate 15, 59–64 (2018).
  29. Marnolia, A., Toepak, E. P. & Tambunan, U. S. F. Fragment-Based Lead Compound Design To Inhibit Ebola Vp35 Through Computational Studies. Int. J. GEOMATE 15, 65–71 (2018).
  30. Anindita, S., Marnolia, A., Putra, H. H. & Tambunan, U. S. F. Novel Inhibitors of T315I Mutant BCR-ABL1 Tyrosine Kinase for Chronic Myeloid Leukemia Disease Through Fragment-Based Drug Design. in ISBRA vol. 10847 185–190 (Springer International Publishing, 2018).
  31. Rizki, I. F., Nasution, M. A. F., Siregar, S. & Tambunan, U. S. F. Screening of Sonic Hedgehog (Shh) Inhibitors in the Hedgehog Signaling Pathway from Traditional Chinese Medicine (TCM) Database Through Structure-Based Pharmacophore Design. Lect. Notes Comput. Sci. 13, 179–184 (2018).
  32. Putra, R. P., Alkaff, A. H., Nasution, M. A. F., Kantale, A. C. B. & Tambunan, U. S. F. Searching of Flavonoid Compounds As a New Antiviral for Sudan Ebolavirus Glycoprotein Using in Silico Methods. Int. J. GEOMATE 15, 78–84 (2018).
  33. Tambunan, U. S. F., Parikesit, A. A., Nasution, M. A. F., Hapsari, A. & Kerami, D. Exposing the molecular screening method of indonesian natural products derivate as drug candidates for cervical cancer. Iran. J. Pharm. Res. (2017) doi:10.22037/ijpr.2017.2088.
  34. Tambunan, U. S. F., Alkaff, A. H., Nasution, M. A. F., Parikesit, A. A. & Kerami, D. Screening of commercial cyclic peptide conjugated to HIV-1 Tat peptide as inhibitor of N-terminal heptad repeat glycoprotein-2 ectodomain Ebola virus through in silico analysis. J. Mol. Graph. Model. 74, 366–378 (2017).
  35. Tambunan, U. S. F. et al. Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation. Drug Target Insights 11, (2017).
  36. Tambunan, U. S. F., Parikesit, A. A., Wardani, F., Nasution, M. A. F. & Kerami, D. In silico study of guanosine triphosphate (GTP) and ribavirin derivatives as the inhibitor for NS5 methyltransferase of dengue virus. Rasayan J. Chem. 10, 910–921 (2017).
  37. Nasution, M. A. F., Aini, R. N. & Tambunan, U. S. F. VIRTUAL SCREENING OF COMMERCIAL CYCLIC PEPTIDES AS β – OG POCKET BINDER INHIBITOR IN DENGUE VIRUS SEROTYPE 2. IOP Conf. Ser. Mater. Sci. Eng. 188, 60–68 (2017).
  38. Zahroh, H. et al. Immunoinformatics approach in designing epitopebased vaccine against meningitis-inducing bacteria (Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae type b). Drug Target Insights 10, 19–29 (2016).
  39. Tambunan, U. S. F., Sipahutar, F. R. P., Parikesit, A. A. & Kerami, D. Vaccine design for H5N1 based on B- and T-cell epitope predictions. Bioinform. Biol. Insights 10, 27–35 (2016).
  40. Tambunan, U. S. F., Chua, W., Parikesit, A. A. & Kerami, D. Designing disulfide cyclic peptide as fusion inhibitor that targets DENV envelope protein. J. Teknol. 78, 95–103 (2016).
  41. Tambunan, U. S. F., Nasution, M. A. F., Parikesit, A. A., Noviardi, H. & Kerami, D. Designing of disulfide cyclic peptide for inhibiting polymerase A and B1 (PAC-PB1N) in H1N1 virus using molecular simulation approach. Online J. Biol. Sci. (2016) doi:10.3844/ojbsci.2016.122.129.
  42. Tambunan, U. S. F., Zahroh, H., Parikesit, A. A., Idrus, S. & Kerami, D. Screening Analogs of beta-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2. Drug Target Insights 9, 33–49 (2015).
  43. Tambunan, U. S. F., Parikesit, A. A., Unadi, Y. C. & Kerami, D. Designing cyclopentapeptide inhibitor of neuraminidase H5N1 virus through molecular and pharmacology simulations. Tsinghua Sci. Technol. (2015) doi:10.1109/TST.2015.7297742.
  44. Prasasty, V. D. et al. 1H, 13C and 15N backbone assignment of the EC-1 domain of human E-cadherin. Biomol. NMR Assign. (2015) doi:10.1007/s12104-013-9539-6.
  45. Tambunan, U. S. F., Rachmania, R. A. & Parikesit, A. A. In silico modification of oseltamivir as neuraminidase inhibitor of influenza A virus subtype H1N1. J. Biomed. Res. (2015) doi:10.7555/JBR.29.20130024.
  46. Bakri, R., Parikesit, A. A., Satriyanto, C. P., Kerami, D. & Tambunan, U. S. F. Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens . Adv. Bioinformatics 2014, 1–10 (2014).
  47. Prasasty, V. D., Tambunan, U. S. F. & Siahaan, T. J. Homology modeling and molecular dynamics studies of ec1 domain of VE-Cadherin to elucidate docking interaction with Cadherin-derived peptide. Online J. Biol. Sci. (2014) doi:10.3844/ojbsci.2014.155.162.
  48. Tambunan, U. S. F., Randy, A. & Parikesit, A. A. Design of candida Antarctica Lipase B thermostability improvement by introducting extra disulfide bond into the enzyme. Online J. Biol. Sci. (2014) doi:10.3844/ojbsci.2014.108.118.
  49. Tambunan, U. S. F., Parikesit, A. A., Dephinto, Y. & Sipahutar, F. R. P. Computational design of drug candidates for influenza a virus subtype H1N1 by inhibiting the viral neuraminidase-1 enzyme. Acta Pharm. (2014) doi:10.2478/acph-2014-0015.
  50. Tambunan, U. S. F., Pratomo, H. & Parikesit, A. A. Modification of Kampmann A5 as Potential Fusion Inhibitor of Dengue Virus using Molecular Docking and Molecular Dynamics Approach. J. Med. Sci. 13, 621–634 (2013).