Division: Organic Chemistry

Title: Lecturer(Lektor – Assistant Professor)

Specialties:

Bioactive Compounds Isolation from Natural Products
Organic Synthesis
Structure Elucidation

Mrs. Rahayu graduated with both Bachelor and Master Degree specialized in Natural Product Chemistry from Institut Teknologi Bandung, Indonesia. She had completed a research project on the phytochemical study of sunflower (Helianthus annuus) leaves and their bioactivity as an antimalarial against Plasmodium falciparum 3D7 strain and cytotoxic against Murine Leukemia P-388 cells during the final year of her Bachelor Degree. Moreover, in her Master Degree, she worked on isolating biflavonoids from leaves and twigs of Agathis robusta (Araucariaceae). These biflavonoids had been examined against Murine Leukemia P-388 cells, anti-angiogenesis as HUVEC proliferation inhibitor, KDR tyrosine kinase inhibitor as an anticancer, and also BACE-1 enzyme inhibitor as an anti-Alzheimer’s. In this project, she had a valuable opportunity to conduct part of her research in the Pharmacognosy and Phytochemistry Division, Meiji Pharmaceutical University, Tokyo, Japan. She started her career as an Organic Chemistry Lecturer in Universitas Indonesia in 2015. Mrs. Rahayu is also a member of the Royal Society of Chemistry.

• Research grant from PT. Pertamina (Persero) on development of imidazoline synthesis as corrosion inhibitor (PI) (2020-now)
• Bright Scientist below 40 Years – FMIPA, Universitas Indonesia (2020)
• Research grant from Universitas Indonesia on isolation, microwave-assisted synthesis, and antibacterial activity of coumarin (PI) (2020)
• Research grant from Universitas Indonesia on development of heterocycles organic synthesis for energy and environmental applications (PI) (2020)
• Research grant from Universitas Indonesia on functional material synthesis development and its application on reduction of environmental pollution (co-PI) (2019)
• South and Southeast Asian University Network (S&SE AUN) Forum on Young Talents on Science and Technology – Yunan, China (2019)
• Research grant from RISTEKDIKTI on Ni/zeolites as heterogenous catalyst for lignin conversion to value added chemicals (co-PI) (2018-2020)
• Research grant from RISTEKDIKTI on metal modified porous materials as heterogeneous catalyst for biomass conversion (co-PI) (2018-2020)
• Research grant from RISTEKDIKTI on Phytochemical study and bioactivity of Kigelia africana fruit as cytotoxic towards breast cancer MCF-7 and leukemia murine P-388 cells (Co-PI) (2018-2020)
• Research grant from Universitas Indonesia on imidazoline-fatty acid derivatives synthesis using MAOS as corrosion inhibitor towards carbon steel (PI) (2018)
• Research grant from PT. Pertamina (Persero) on zeolite for RFCC catalyst (co-PI) (2016-2018)
• Research grant from PT. HM Sampoerna Tbk. (Phillip Morris Indonesia) on the chemical composition and structures in cloves responsible for their flavours (co-PI) (2016-2018)
• The Best Lecturer based on Student Evaluation – FMIPA, Universitas Indonesia (2016)

• PN Amalia, I Abdullah, DUC Rahayu, YK Krisnandi, Synthesis and Characterization of Copper Impregnated Mesoporous Carbon as Heterogeneous Catalyst for Phenylacetylene Carboxylation with Carbon Dioxide, Indonesian Journal of Chemistry, 21(1), 77-87, 2021. https://doi.org/10.22146/ijc.52778
• H Dianhar, AW Winata, S Handayani, P Sugita, DUC Rahayu, The Effect of Various Phenolics in p-TsOH Catalyzed Solvent-Free Microwave-Assisted Synthesis of 4-Methyl Coumarin Derivatives, Rasayan Journal of Chemistry, 13(3), 1801-1806, 2020.http://dx.doi.org/10.31788/RJC.2020.1335808
• P Sugita, R Amilia, B Arifin, DUC Rahayu, H Dianhar, The Phytochemical Screening Hexane and Methanol Extract of Sinyo Nakal (Duranta repens), Asian Journal of Pharmaceutical and Clinical Research, 13(8), 196-200, 2020.http://dx.doi.org/10.22159/ajpcr.2020.v13i8.38165
• DUC Rahayu, DA Setyani, H Dianhar, P Sugita, Phenolic Compounds from Indonesian White Turmeric (Curcuma zedoaria) Rhizomes, Asian Journal of Pharmaceutical and Clinical Research, 13(7), 194-198, 2020. http://dx.doi.org/10.22159/ajpcr.2020.v13i7.38249
• AP Pratama, DUC Rahayu, YK Krisnandi, Levulinic Acid Production from Delignified Rice Husk Waste over Manganese Catalysts: Heterogeneous Versus Homogeneous, Catalysts, 10, 327, 1-13, 2020. https://doi.org/10.3390/catal10030327
• P Sugita, N Jannah, DUC Rahayu, Two Flavanones from Finger-Root (Curcuma rotunda) and Its Antibacterial Activities, Rasayan Journal of Chemistry, 13(1), 322-326, 2020. http://dx.doi.org/10.31788/RJC.2020.1315484
• W Darmawan, DA Nurani, DUC Rahayu, I Abdullah, Synthesis of Ion Imprinted Polymer for Separation and Preconcentration of Iron (III), AIP Conference Proceedings, 2242, 040025, 2020. https://doi.org/10.1063/5.0008283
• A Rachman, DUC Rahayu, AP Gustianthy, YK Krisnandi, Optimization of Butanolysis Reaction: Synthesis of Alkyl Polyglycoside (APG) from 1-Butanol and Glucose for Enhanced Oil Recovery (EOR) Application, AIP Conference Proceedings, 2242, 040019, 2020. https://doi.org/10.1063/5.0008004
• DUC Rahayu, JE Hutauruk, YK Krisnandi, E Saepudin, Oil Palm Empty Fruit Bunch (OPEFB) (Elaeis guineensis Jacq.) Cellulose Conversion into Levulinic Acid using Hierarchical Mn/ZSM-5 Heterogeneous Catalyst, IOP Conference Series: Materials Science and Engineering, 763, 012034, 2020. https://doi.org/10.1088/1757-899X/763/1/012034
• MP Laksmi, DA Nurani, DUC Rahayu, Polymerization of the Tannin Extract from the Leave of Acacia mangium and Its Application as an Adsorbent for the Removal of Lead, Journal of Physics: Conference Series, 1442, 012058, 2020. https://doi.org/10.1088/1742-6596/1442/1/012058
• A Nabilah, S Handayani, S Setiasih, DUC Rahayu, S Hudiyono, Esterification of Oxidized Ricinoleic Acid with Various Alcohols to Produce Emulsifier and Antimicrobial Compounds, AIP Conference Proceedings, 2237, 020021, 2020. https://doi.org/10.1063/5.0005809
• A Nabilah, S Handayani, S Setiasih, DUC Rahayu, S Hudiyono, Esterification of Oxidized Ricinoleic Acid with Various Alcohols to Produce Emulsifier and Antimicrobial Compounds, AIP Conference Proceedings, 2237, 020021, 2020. https://doi.org/10.1063/5.0005809
• NH Adriani, DUC Rahayu, E Saepudin, Activity of Hydrogenated Curcuminoid on Pd/C Catalyst and Its Antibacterial Activity against Staphylococcus Aureus and Streptococcus Mutans, IOP Conference Series: Materials Science and Engineering, 902, 012068, 2020. https://doi.org/10.1088/1757-899X/902/1/012068
• DUC Rahayu, D Nurfadhilah, P Sugita, Phytochemical Study of Indonesian Curcuma rotunda Rhizome and Its Antioxidant Activity towards 1,1-Diphenyl-2-Picrylhydrazyl (DPPH), International Journal of Pharmaceutical Sciences and Research, 10(7), 3354-3358, 2019.
• AI Baihaqi, DUC Rahayu, E Budianto, Effect of Drug Loading Method on Drug Dissolution Mechanism of Amoxicillin Trihydrate Encapsulated in Chitosan-Poly(N-Vinylpyrrolidone) Full-IPN Hydrogel as a Floating Drug Delivery System Matrix, Material Science Forum, 964, 251-256, 2019. https://doi.org/10.4028/www.scientific.net/MSF.964.251
• P Sugita, SO Firdaus, Kurniawanti, DUC Rahayu, L Nurhayati, A Ilmiawati, T Wukirsari, Sesquiterpenes from Indonesian Curcuma aeruginosa Rhizome and Its Antibacterial Activities, Journal of Pharmacy Research, 11(2), 386-390, 2019.
• II Lestari, DUC Rahayu, DA Nurani, YK Krisnandi, E Budianto, Ethylenediamine-Derived Imidazoline Synthesis using MAOS (Microwave Assisted Organic Synthesis) Method, AIP Conference Proceedings, 2168, 020066, 2019. https://doi.org/10.1063/1.5132493
• P Sugita, SO Firdaus, A Ilmiawati, DUC Rahayu, Curcumenol: A Guaiane-Type Sesquiterpene from Indonesian Curcuma heyneana Rhizome and Its Antibacterial Activity towards Staphylococcus aureus and Escherichia coli, Journal of Chemical and Pharmaceutical Research, 10(6), 68-75, 2018.
• DUC Rahayu, Hartono, P Sugita, Antibacterial Activity of Curcumenol from Rhizomes of Indonesian Curcuma aeruginosa (Zingiberaceae), Rasayan Journal of Chemistry, 11(2), 762-765, 2018. http://dx.doi.org/10.31788/RJC.2018.1122076
• P Sugita, N Octviana, T Wukirsari, DUC Rahayu, Chemical Constituent and Antioxidant Activity of Methanol Extract from Indonesian Curcuma aeruginosa Roxb. Rhizome, Journal of Pharmacy Research, 12(3), 293-297, 2018.
• DUC Rahayu, SN ’Adilah, P Sugita, Antioxidant Activity of Methanol Extract from Indonesian Curcuma heyneana Rhizome, European Journal of Pharmaceutical and Medical Reserach, 5(3), 582-588, 2018.
• RHS Siti, P Sugita, L Ambarsari, DUC Rahayu, Antibacterial Mangosteen (Garcinia mangostana Linn.) Peel Extract Encapsulated in Chitosan, Journal of Physics: Conference Series, 1116, 042037, 2018.https://doi.org/10.1088/1742-6596/1116/4/042037
• AH Cahyana, P Salsabila, B Ardiansah, DUC Rahayu, Magnetically Recoverable Fe3O4@SiO2@Sm: Preparation and Application in One-Pot, Three-Component Assembly of Bis(Phenyl-1H-Pyrazol-5-Ol) Derivatives, AIP Conference Proceedings, 2023, 020069, 2018. https://doi.org/10.1063/1.5064066
• B Amelia, E Saepudin, AH Cahyana, DUC Rahayu, AS Sulistyoningrum, J. Haib, GC-MS analysis of clove (Syzygium aromaticum) bud essential oil from Java and Manado, AIP Conference Proceedings, 1862, 030082, 2017. http://doi.org/10.1063/1.4991186
• AH Cahyana, D Fitria, B Ardiansah, DUC Rahayu, Preparation of Fe3O4/SiO2-Guanidine Organobase Catalyst for 1,5-Diphenylpenta-2,4-Dien-1-One Synthesis, IOP Conference Series: Materials Science and Engineering, 188, 012026, 2017. https://doi.org/10.1088/1757-899X/188/1/012026

Patents

• YK Krisnandi, Z Paputungan, D Triyono, DA Nurani, DUC Rahayu, Sirkuit IDC Termodifikasi Komposit Hibrida Zeolit sebagai Sensor Gas Amonia (IDC Circuit Modification based on Hybrid Zeolite Composite as Ammonia Gas Sensor, 2020, Indonesian Patent, IDP000069591.
• YK Krisnandi, E Saepudin, DA Nurani, DUC Rahayu, R Pertiwi, NF Antra, A Agnes, AP Azaria, AR Anggraini, AP Pratama, Proses Pembuatan Asam Levulinat dari Limbah Sekam Padi Terdelignifikasi menggunakan Katalis Heterogen Mn3O4/ZSM-5 Berpori Hierarki (Production Process of Levulinic Acid from Delignified Rice Husks using Hierarchical Mn3O4/ZSM-5 Heterogenous Catalyst), 2020, Indonesian Patent, IDP000071846.

Conferences

• DUC Rahayu, B Andreana, S Budiana, II Lestari, A Yuniastuti, M Mujahiduzzakka, MI Andra, DA Nurani, I Abdullah, YK Krisnandi, Microwave Assisted Synthesis of Imidazoline Derivatives for Corrosion Inhibitor, Green Chemistry New Zealand (GCNZ), 2 – 5 December 2019, Auckland, New Zealand. (Oral Presenter)
• DUC Rahayu, AP Pratama, YK Krisnandi, Synthesis of Levulinic Acid from Delignified Rice Husk using Mn2+, MnO2, and Hierarchical Mn3O4/ZSM-5 Heterogeneous Catalysts, The 7th European Chemical Society (EuCheMS) Chemistry Congress, 26 – 30 August 2018, Liverpool, United Kingdom. (Poster Presenter)
• DUC Rahayu, JE Hutauruk, YK Krisnandi, E Saepudin, Cellulose Conversion from Oil Palm Empty Fruit Bunch (OPEFB) (Elaeis guineensis Jacq.) into Levulinic Acid using Hierarchical Mn/ZSM-5 Heterogeneous Catalyst, The 3rd International Symposium on Current Progress in Functional Materials (ISCPFM), 8 – 9 August 2018, Depok, Indonesia. (Oral Presenter)
• DUC Rahayu, Hartono, P Sugita, Antibacterial Activity of Curcumenol from Rhizomes of Indonesian Curcuma aeruginosa (Zingiberaceae), SEMIRATA International Conference on Science and Technology (ICST), 4 – 6 May 2018, Medan, Indonesia. (Oral Presenter)
• DUC Rahayu, DA Nurani, LNH Rochmah, NF Antra, YK Krisnandi, Cellulose Conversion from Mahogany Woodsare to Levulinic Acid by using Hierarchical Mn/ZSM-5 Heterogeneous Catalyst, The 2nd International Symposium on Current Progress in Functional Materials (ISCPFM), 8 – 9 November 2017, Bali, Indonesia. (Oral Presenter)